February 27, 2020
anxiety brain

The secret of anxiety is hidden in the development of the brain, to know how the study was done

There can be many reasons for mental disorders in humans, such as anxiety. However, recent research studies have focused on a completely different approach in order to find the reasons behind it. New research has shown that developmental changes in the human brain may be a cause for concern. Neurochemicals such as dopamine and serotonin play important roles in the functioning of the human brain’s emotional and cognition systems.

Vesicular monoamine transporter 1 (VMAT1) is one of many genes widely responsible for controlling neuronal signalling and the transport of neurotransmitters. The research team at the University of Tohoku has reconstructed the VMAT1 protein for their study. Through this, changes in the functioning of the brain were claimed. This change occurred in neurotransmitters during the use of VMAT1 during human development.

Study done like this
Researcher Professor Masakado Quata and researcher Daiki Sato of the Tohoku University Graduate School of Life Sciences found in their earlier study that VMAT1 is a gene that has evolved in the course of human development. VMAT1 has two mutations or altered variants of the genome, especially in humans. Researchers in the study claimed that the developmental changes in the use of neurotransmitters were present through the reconstruction of the VMAT1 protein in the ancestors.

A fluorescent layer was then applied to each genotype in order to observe and quantify the use of neurotransmitters. In the meantime, they have found that the VMAT1 protein in our ancestors showed higher levels of neurotransmitters than the genotype associated with stress or anxiety in contemporary humans.

It is important to understand the evolution
The authors of this study reported, ‘Our study results showed that our ancestors were able to withstand high levels of anxiety or depression.’ Now researchers want to focus on what different things played an important role in the development of our brain.

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